Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. If you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you may be wondering what caused losing and worry about whether it’ll happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a child to develop normally it is essential that it have exactly the right quantity of chromosome material; missing or extra material at the time of conception or within an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or higher for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is a lot more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage continue to possess a healthy pregnancy and never miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in past times the miscarriage would have appeared to be just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason for the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that is passed at home is often unable to be tested with this particular method. pregnancy About 20% or even more of miscarriage samples neglect to grow and thus no results are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is available, it may be the correct result for the fetus or it can be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is a new type of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more prone to receive results and the results are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

In case a chromosome abnormality is identified, the type of abnormality found can be assessed to help answer fully the question: “Will this happen to me again?”. Quite often, chromosome abnormalities in an embryo or fetus are not inherited and have a minimal chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your doctor to do further studies to research the possibility of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason for a pregnancy loss might help a couple start the emotional healing up process, moving past the question of “Why did this happen to me?”.

Chromosome testing could be especially very important to patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason behind the miscarriages and allow their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having an effective healthy pregnancy.

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