Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you may be wondering what caused losing and worry about whether it’ll happen again. pregnancy This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What type of genetic testing is available for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is important that it have exactly the right quantity of chromosome material; missing or extra material during conception or in an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are due to chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is a lot more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother ages.

Most women who experience a miscarriage continue to possess a healthy pregnancy and never miscarry again. However, some women appear to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this can be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas in past times the miscarriage would have were just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many types of testing that can be done on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. Due to this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples neglect to grow and thus no results are available. Additionally, karyotyping struggles to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is found, it may be the correct result for the fetus or it might be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new type of genetic testing done on miscarriage samples; the two most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be able to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more likely to receive results and the results are typically returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood concurrently the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the kind of abnormality found could be assessed to help answer the question: “Will this happen to me again?”. More often than not, chromosome abnormalities within an embryo or fetus aren’t inherited and have a low possiblity to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your doctor to do further studies to investigate the chance of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the explanation for a pregnancy loss can help a couple of start the emotional healing process, moving past the question of “Why did this eventually me?”.

Chromosome testing can be especially very important to patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and allow their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having a successful healthy pregnancy.

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